Alpha Glucosidase Inhibitors

Alpha glucosidase inhibitors are used in type II diabetes and function by decreasing available glucose for digestion by inhibiting the enzyme, alpha-glucosidase.  Alpha-glucosidase breaks down complex carbohydrates in the gut.  Gastrointestinal disturbances are common with use of these medications.

Class Drugs

• Acarbose

• Miglitol

Class Mechanism of Action

Inhibits alpha-glucosidase enzyme in brush border of intestines

• Decreases breakdown of complex carbohydrates into simple sugars that can be absorbed

Class Applications

Type II Diabetes Mellitus

Class Adverse Effects

Flatulence, diarrhea, abdominal cramping

• Special caution in patients with inflammatory bowel conditions

Drug Table

Drug Name	Application	Comments	Image
Acarbose			"Car" "Bose Speaker"
Miglitol			"Mag Light"