Antimuscarinic Drugs (Bladder)

These are antimuscarinic drugs used primarily in the treatment of overactive bladder. These drugs have preferential inhibition of bladder muscarinic receptors. Blockage of the bladder muscarinic receptors induces relaxation of the bladder, which reduces spasms and allows the bladder to fill more fully prior to emptying.

Class Drugs

• Darifenacin

• Fesoterodine

• Oxybutynin

• Solifenacin

• Tolterodine

• Trospium

Class Application

• Overactive Bladder

Class Mechanism of Action

• Blocks muscarinic receptors

Relaxes bladder muscle and decreasing spasms, thus allowing bladder to fill more fully before emptying

• Blocks sympathetic cholinergic receptors

Class Adverse Effects

• Blind as a bat (mydriasis)

• Red as a beet (erythema)

• Dry as a bone (dry mouth/skin/eyes)

• Hot as hades (hyperthermia)

• Mad as a hatter (delirium)

• Urinary retention

• Constipation

Drug Table

Drug Name	Application	Comments	Image
Darifenacin	Overactive bladder		"DARE shirt" "Fence"
Fesoterodine	Overactive bladder		"Fast Rodent"
Oxybutynin	Overactive bladder		"Ox Butting In"
Solifenacin	Overactive bladder		"Solar Panel" "Fence"
Tolterodine	Overactive bladder		"Turtle Dining"
Trospium	Overactive bladder		Guy "trying to spy on them"