Aspirin

Aspirin is a widely used irreversible inhibitor of COX-1, which results in the reduction of thromboxane A2 levels.  Thromboxane A2 plays an important role in recruitment and activation of platelets.  The effects of aspirin last for 7-10 days (length of platelet life).  Aspirin is used in the treatment of ACS, prophylaxis against ACS, and prophylaxis for stroke.  Aspirin is also an analgesic.  Bleeding is the main side effect. Aspirin should not be used during illness for pediatric patients because use has been associated with the development of Reye's syndrome. Reye's syndrome can result in seizures and liver damage.  

Class Drugs

• Aspirin

Class Mechanism of Action

Irreversible COX-1 Inhibitor

• Acetylates serine on active site of COX-1

• Reduces production of Thromboxane A2

• Effects last the life of the platelet (7-10 days)

• Should be taken 1 hour before or 8 hours after ibuprofen to avoid competition at COX-1 sites and decreased platelet inhibition

Aspirin mechanism diagram

Class Applications

Treatment of acute coronary syndrome

Prophylaxis of acute coronary syndrome

Prophylaxis of stroke

Class Adverse Effects

Increased incidence of bleeding (GI, hemorrhagic stroke, etc.)

Reye's syndrome has been linked to aspirin use in pediatric patients when used during/after flu-like illness and should be avoided.

Drug Table

Drug Name	Application	Comments	Image
Aspirin			"Aspirin Bottle"