Benzodiazepine Antagonists

Flumazenil is a competitive benzodiazepine antagonist used to reverse the effects of benzodiazepines.  Situations where flumazenil is used include in overdose events and for reversal of sedation.  The medication is short-acting so several doses may be required.  Flumazenil can precipitate benzodiazepine withdrawal so care in administration must be taken as seizures may be precipitated.  

Class Drugs

• Flumazenil

Class Mechanism of Action

GABA receptor antagonist

Class Application

Reversal of benzodiazepines

Class Adverse Effects

Seizures

• Can precipitate seizures in patients dependent on benzodiazepines or in patients who are using benzodiazepines to treat seizures.

Dizziness

Nausea

Vomiting

Agitation

Drug Table

Drug Name	Application	Comments	Image
Flumazenil	Benzodiazepine Reversal		"Flu Shot" and "Maze"