Centrally Acting Alpha Agonists

Clonidine and Methyldopa act centrally on α2 receptors.  Stimulation of these receptors inhibits sympathetic outflow to periphery from vasomotor sensors resulting in lower blood pressure.

Class Drugs

• Clonidine

• Methyldopa

Class Mechanism of Action

• Central α2 agonist. Stimulation of these receptors inhibits sympathetic outflow to periphery from vasomotor sensors resulting in lower blood pressure.

Class Application

Hypertension

Class Adverse Effects

• Sedation

• Constipation

• Lethargy

• Rebound hypertension upon discontinuation

Drug Table

Drug Name	Application	Comments	Image
Clonidine	Hypertension; Opioid Withdrawal; Anxiety		"Claw" and "Dining Table"
Methyldopa	Hypertension	Rarely used due to need for frequent dosing	"Meth" and "Dope"