Ergot Alkaloids

Ergot alkaloids are medications used for the treatment of migraine headaches. These medications work by causing cerebral vasoconstriction by exerting effects on many receptors including alpha, dopamine, and serotonin receptors.  Due to the vasoconstricting effects of ergot alkaloids, these medications are contraindicated in patients with angina and peripheral vascular disease.

Class Drugs

• Ergotamine

• Dihydroergotamine

Class Mechanism of Action

Binds multiple receptors including alpha, dopamine, and serotonin on intracranial blood vessels resulting in vasoconstriction

Class Applications

Migraine headaches

Class Adverse Effects

Nausea

Contraindicated in peripheral vascular disease and in patients with angina due to vasoconstrictive effects

Drug Table

Drug Name	Application	Comments	Image
Ergotamine			"Erg" "Otoscope" "Mine"
Dihydroergotamine			"Two Hydro Flasks" "Erg" "Otoscope" "Mine"