Fidaxomicin

Fidaxomicin is used for the treatment of C. difficile diarrhea. Fidaxomicin works by inhibiting the bacterial RNA polymerase enzyme at the site of transcription.  Fidaxomicin is bactericidal and there is minimal resistance.  Expected gastrointestinal side effects are present.

Class Drugs

• Fidaxomicin

Class Mechanism of Action

Inhibits bacterial RNA polymerase at transcription

Bactericidal

Class Applications

C. difficile diarrhea

• Minimal absorption in oral, so remains in GI tract

Class Adverse Effects

Resistance

• Minimal resistance

N/V/Abdominal pain

Hypersensitivity

Drug Table

Drug Name	Application	Comments	Image
Fidaxomicin			"Fido" "Axe" "Mice"