Fondaparinux

Fondaparinux works similarly to heparin/LMWH but it is synthetic. Fondaparinux binds to antithrombin III, which potentiates inactivation of factor Xa and results in reduced coagulation.  Fondaparinux is used in the treatment of DVT/PE and in DVT prophylaxis.  Fondaparinux is not approved for the treatment of HIT by the FDA, but is used for this indication "off-label."

Class Drugs

• Fondaparinux

Class Mechanism of Action

• Similar action to heparin/LMWH but synthetically derived: Binds to antithrombin III, which potentiates inactivation of factor Xa

Decreased factor Xa levels reduces coagulation

Site of action in the coagulation cascade of fondaparinux

Class Applications

Treatment of DVT/PE

• Prevents fibrin formation

DVT prophylaxis in post-operative period for abdominal and orthopedic surgeries

Class Adverse Effects

• Bleeding, can be life threatening

Reversal agent not available

• Heparin Induced Thrombocytopenia (HIT) is still possible but is unlikely. Fondaparinux is used "off-label" for treatment of HIT.

• Contraindicated in severe renal impairment

Drug Table

Drug Name	Application	Comments	Image
Fondaparinux			"Fondue" "Pear" "Knuckles"