Gonadotropin-Releasing Hormone Analogs

Analogs of gonadotropin-releasing hormone are primarily used to treat hormone dependent cancers and other hormone dependent conditions.  Continuous administration results in decreased FSH and LH levels. Lower FSH and LH levels decrease release of gonadal steroid hormones, which is the source of the drug's effectiveness for hormone dependent conditions.  

Hot flashes, ovarian cysts, depression, and gynecomastia are notable adverse effects.

Class Drugs

• Leuprolide

• Goserelin

• Nafarelin

• Histrelin

Class Mechanism of Action

Continuous administration decreases release of FSH and LH results in decreased production of gonadal steroid hormones

• Useful in treatment of hormone dependent cancers and other hormone dependent conditions such as endometriosis and uterine fibroids.

Pulsatile administration increases the production and release of FSH and LH

Class Applications

Prostate cancer treatment

Endometriosis

Precocious puberty

Class Adverse Effects

Hot flashes

Sweating

Depression

Ovarian cysts

Gynecomastia in males

Drug Table

Drug Name	Application	Comments	Image
Leuprolide			"Loops" "Roll"
Goserelin			"Goose" "Relic"
Nafarelin			"Bus Fare" "Relic"
Histrelin			"History Book" "Relic"