Granulocyte Colony-stimulating Factors

Granulocyte Colony-stimulating factors (G-CSF) are medications that work to stimulate the production and release of neutrophils from the bone marrow in the same fashion as human G-CSF. G-CSF is used to prevent neutropenia and infections related to myelosuppressive chemotherapy.  Filgrastim is a recombinant form of human G-CSF. Pegfilgrastim is a pegylated from of filgrastim to increase the duration of action.

Class Drugs

• Filgrastim

• Pegfilgrastim

Class Mechanism of Action

• Stimulates production and release of neutrophils from the bone marrow.

Class Applications

• Severe chronic neutropenia

• Severe neutropenia associated with myelosuppressive treatments

• Cancer patients undergoing bone marrow transplant

Class Adverse Effects

• Bone pain

• Rare risk of splenic rupture

Drug Table

Drug Name	Application	Comments	Image
Filgrastim			"Dr. Phil" "Grass"
Pegfilgrastim			"Peg" "Dr. Phil" "Grass"