Mineralocorticoids

Fludrocortisone is used in settings of mineralocorticoid deficiency to assist in regulating salt and water balance. Fludrocortisone administration increases sodium, bicarbonate, and water reabsorption in the distal tubules.  Calcium reabsorption is reduced, so osteoporosis can develop with long-term use.     

Class Drugs

• Fludrocortisone

Class Mechanism of Action

Replaces aldosterone effects from adrenal glands

• Increases reabsorption of sodium, bicarbonate and water in distal tubules

• Decreases reabsorption of potassium and hydrogen ions

Glucocorticoid effects

Class Applications

Primary or Secondary Adrenocortical Insufficiency (Addison's Disease)

Class Adverse Effects

Osteoporosis

• Results from decreased calcium absorption, decreased sex hormone synthesis, and decreased bone formation

• Primarily in long-term use

Acute adrenal insufficiency in abrupt withdrawal of long-term steroid use

Hypernatremia, hypokalemia

Drug Table

Drug Name	Application	Comments	Image
Fludrocortisone			"Flood" "Row" "Corn" "Ozone"