Non-nucleoside Reverse Transcriptase Inhibitors

Non-nucleoside reverse transcriptase inhibitors are used to treat HIV and work by inhibiting the HIV reverse transcriptase enzyme. Non-nucleoside reverse transcriptase inhibitors differ from nucleoside and nucleotide reverse transcriptase inhibitors because non-nucleosides bind to an allosteric site near the active site of the enzyme, causing a conformational change that renders the reverse transcriptase ineffective. 

Class Drugs

• Efavirenz

• Etravirine

• Nevirapine

• Rilpivirine

Class Mechanism of Action

Binds to allosteric site near active site inducing an active site change, rendering reverse transcriptase ineffective

Class Applications

HIV

Class Adverse Effects

• Hypersensitivity

• Rash

Drug Table

Drug Name	Application	Comments	Image
Efavirenz		Adverse Reactions; Drug-Drug Interactions	"Fave Reds"
Etravirine	HIV Resistant to 1st Gen	Second Generation NNRTI; Adverse Reactions; Drug-Drug Interactions	"Extra" "Irene"
Nevirapine	Hepatitis B	Adverse Reactions; -Toxic Epidermal Necrolysis; -Stevens-Johnson Syndrome; -Fatal Hepatotoxicity	"Never" "Pine"
Rilpivirine			"Rip" "Virus"