Progesterone Antagonists

Mifepristone is a progesterone antagonist that is used for induction of abortion in early pregnancy.  Generally, mifepristone is administered with misoprostol, which is a prostaglandin, to induce myometrial contractions, detachment, and expulsion of the pregnancy.  

Class Drugs

• Mifepristone

Class Mechanism of Action

Competitive antagonist of progesterone and glucocorticoid receptors

Class Applications

Induction of abortion in early pregnancy (generally used in combination with misoprostol)

• Combination induces myometrial contractions, detachment, and expulsion of pregnancy.

 

Class Adverse Effects

Incomplete abortion

Uterine bleeding

Drug Table

Drug Name	Application	Comments	Image
Mifepristone			"Miffed" "Rhinestone"