Retinoids

Retinoids are a class of medications that are used in the treatment of acne vulgaris. Some medications in this class also have indications for treatment of fine lines associated with photoaging.  In acne, retinoids work by unclogging blocked pores. In photoaging, retinoids improves the collagen and dermal matrix. Skin irritation and photosensitivity are common side effects.  These medications should not be taken/handled in pregnancy due to risk of birth defects.

Class Drugs

• Tretinoin

• Isotretinoin

• Adapalene

• Tazarotene

Class Mechanism of Action

Comedolytic, which allows unclogging of blocked pores in the treatment of acne

Improves collagen and dermal matrix, which is useful in slowing photo-aging from UV exposure

Class Applications

• Comedonal and inflammatory acne

• Psoriasis

• Post-inflammatory hyperpigmentation

• Photoaging

Class Adverse Effects

• Irritation and skin dryness

• Photosensitivity

• Contraindicated in pregnancy, due to risk of birth defects

Drug Table

Drug Name	Application	Comments	Image
Tretinoin			"Tree" "Tin" "Onion"
Isotretinoin	Severe Acne	Adverse Effects; -Only oral form of retinoids; -Very high risk of birth defects in pregnancy	"Ice" "Tree" "Tin" "Onion"
Adapalene			"Ad" "Pal"
Tazarotene	Acne; Psoriasis; Wrinkles		"Tasmanian" "Rotini Noodles"