Sodium Channel Blocker: Ranolazine

Ranolazine is a sodium channel blocker that is used in the treatment of chronic stable angina and works by inhibiting the late sodium current. Ranolazine is a sodium channel blocker that reduces intracellular sodium and calcium in cardiac myocytes, which improves cardiac relaxation in the diastolic phase.  Ranolazine has multiple drug interactions and prolongs the QT interval.  

Class Drugs

• Ranolazine

Class Mechanism of Action

Sodium Channel Blocker

• Decreases intracellular sodium and calcium, improving cardiac relaxation in diastole

Class Applications

Stable angina

• Improved diastolic function

• Also had antiarrhythmic properties

Class Adverse Effects

• Multiple drug interactions via CYP3A, CYP2D6, and P-glycoprotein

• QT prolongation

Drug Table

Drug Name	Application	Comments	Image
Ranolazine			"Rambo" "Laz-y-Boy"