Vitamin D Analogs

Calcipotriene and topical calcitriol are used primarily in the treatment of psoriasis. These medications work by inhibiting the proliferation of keratinocytes and by promoting the differentiation of keratinocytes to promote normal epidermal growth.  The effects likely stem from interactions with the vitamin D receptor.  Adverse effects can include hypercalcemia.  

Class Drugs

• Calcipotriene

• Calcitriol

Class Mechanism of Action

Inhibit increase in keratinocytes

Promotes keratinocyte differentiation

Reduces IgE mediated inflammation

Class Applications

Psoriasis (topically)

Class Adverse Effects

Hypercalcemia

Itching/dryness/irritation

Drug Table

Drug Name	Application	Comments	Image
Calcipotriene	Psoriasis		"Calcium" "Pot" "Trying"
Calcitriol (Topical)	Psoriasis		"Calcium" "Tri-tater"