5HT2 Receptor Antagonists

Trazodone and nefazodone both block postsynaptic serotonin 5HT2a as the class name implies.  Both medications are quite sedating and are taken at night, which can aid in treating patients with both depression and difficulty sleeping.  Trazodone is known to cause priapism and nefazodone is known to lead to increased appetite and weight gain.

Class Drugs

• Trazodone

• Nefazodone

Class Mechanism of Action

• Weak serotonin reuptake inhibitor

• Blocks postsynaptic 5HT2a receptors.

• Antihistamine

Class Application

• Depression

Class Adverse Effects

• Sedation

• Dizziness

• Priapism - Trazodone

• Hepatotoxicity - Nefazodone

Drug Table

Drug Name	Application	Comments	Image
Trazodone	Depression	Priapism	"Travis" and "Bone"
Nefazodone	Depression	Hepatotoxicity	"Nerf Ball" and "Dome"