Atypical Antidepressants

Bupropion and mirtazapine are atypical antidepressants.  These medications are related to tricyclic antidepressants (TCAs). Bupropion is used for both depression and for smoking cessation. Bupropion lowers the seizure threshold.  Mirtazapine is known to cause weight gain.   

Class Drugs

• Bupropion

• Mirtazapine

Class Mechanism of Action

• See individual drugs.

Class Application

• Depression

Class Adverse Effects

• See individual drugs.

Drug Table

Drug Name	Application	Comments	Image
Bupropion	DepressionSmoking cessation	Mechanism; Weak dopamine and NE reuptake inhibitor; Adverse Effects; -Lowers seizure threshold; -Nervousness; -Tremor; -Dry mouth; -Low incidence of sexual dysfunction	Ghost saying 'boo' and "Prop"
Mirtazapine	Depression	Mechanism; Antagonist to presynaptic alpha 2 receptors, which enhances NE and serotonin transmission; Adverse Effects; -Sedation; -Increased appetite and weight gain; -Low incidence of sexual dysfunction	"Mirror" and "Tasmanian Devil"