Amylin Analogs

Pramlintide is an amylin analog.   Amylin is secreted by the pancreas and works with insulin to reduce blood sugar levels.  Amylin slows gastric emptying, reduces appetite and decreases glucagon secretion.  Care must be taken when administering pramlintide as hypoglycemia can occur, which can be profound. Because amylin slows gastric emptying, diabetic gastroparesis can be exacerbated.

Class Drugs

• Pramlintide

Class Mechanism of Action

Synthetic form of amylinAmylin works by

• Delay of gastric emptying

• Decreases secretion of glucagon

• Increases satiety

Class Applications

Diabetes mellitus

• Adjunct to insulin at mealtime for TIDM and TIIDM

Class Adverse Effects

Hypoglycemia, can be profound, insulin use should be cut in half when initiating therapy

Avoid in diabetic gastroparesis

Cresol hypersensitivity

Drug Table

Drug Name	Application	Comments	Image
Pramlintide			"Pray" "Lint" "Tide"