GLP-1 Agonists

GLP-1 analogs such as exenatide are used in the treatment of type II diabetes.  GLP-1 analogs work in the same manner as endogenous GLP-1 by stimulating insulin secretion, slowing gastric emptying, improving satiety, and decreasing glucagon secretion.  Semaglutide and liraglutide also have an indication for use in weight management.  Pancreatitis is one known serious side effect.

Class Drugs

• Dulaglutide

• Exenatide

• Liraglutide

• Semaglutide

Class Mechanism of Action

GLP-1 analogs

• GLP-1 is secreted in response to oral glucose intake; however, in TIIDM, GLP-1 response to oral glucose is diminished

• GLP-1

Stimulates insulin secretion

• Delays gastric emptying

• Increases satiety

• Decreases postprandial glucagon secretion

• Promotes increase in number of beta cells

Class Applications

Type II Diabetes mellitus

• Provides baseline glycemic control

Weight management (semaglutide, liraglutide)

Class Adverse Effects

Pancreatitis

Nausea

Vomiting

Diarrhea

Drug Table

Drug Name	Application	Comments	Image
Dulaglutide	Reduced cardiac events in patients with TIIDM; TIIDM		"Doula" "Glue" "Tide"
Exenatide	DM II		"Exxon" "Tide"
Liraglutide	DM IIWeight Management		"Libra" "Glue" "Tide"
Semaglutide	DM II; Weight management		"Semi" "Glue" "Tide"