Beta Blockers with Partial Agonist Activity

Acebutolol and Pindolol inhibit β1 and β2 receptors competitively.  These medications partially stimulate the receptors but are much weaker than the endogenous hormones, which results in the medication's effects.  These medications are useful in treating hypertension in patients with bradycardia as the medications do not cause as significant of a heart rate drop as other beta blockers.

Class Drugs

• Acebutolol

• Pindolol

Class Mechanism of Action

• Beta antagonist with partial agonist activity

Class Application

Hypertension

• Negative inotrope but less chronotropic effects

• Useful in patients with bradycardia as there is less rate related changes.

Class Adverse Effects

• Bronchoconstriction

• Arrhythmias

• Depression

• Dizziness

• Fatigue

• Sexual dysfunction

Drug Table

Drug Name	Application	Comments	Image
Acebutolol	Hypertension; Angina; Ventricular Arrhythmias		"Ace of Hearts" and "Lollipop"
Pindolol	Hypertension		"Pin" and "Lollipop"