Nonselective Beta Blockers with Alpha-1 Blockade

Labetalol and carvedilol block both β and α1 receptors.  The α1 effects (vasodilation) add to the β effects caused by other beta blockers.  These medications are used in the treatment of hypertension.  Fatigue, dizziness, sexual dysfunction, and bronchoconstriction are all possible side effects.

Class Drugs

• Labetalol

• Carvedilol

Class Mechanism of Action

• Beta antagonist with concurrent alpha-1 antagonist activity

Class Application

Hypertension

• Negative inotrope and chronotrope (Beta-1)

• Vasodilatory alpha effect (alpha-1)

Adverse Effects

• Bronchoconstriction

• Arrhythmias

• Depression

• Dizziness

• Orthostatic hypotension

• Fatigue

• Sexual dysfunction

Drug Table

Drug Name	Application	Comments	Image
Labetalol	Hypertension; Hypertensive Emergency	Used frequently in hypertension in pregnancy	"Labrador" and "Lollipop"
Carvedilol	Hypertension; Angina; LV Dysfunction Following Myocardial Infarction		"Pin" and "Lollipop"