Chloride Channel Activators

Lubiprostone is a medication that is indicated in the treatment of constipation and works by activating gut chloride channels.  Activation of gut chloride channels results in increased fluid secretion in the intestinal lumen.  Increased fluid in the intestinal lumen aids in stool passage and softness.

Class Drugs

• Lubiprostone

Class Mechanism of Action

Activates gut chloride channels, increasing fluid secretion into GI tract

Class Applications

Constipation

Class Adverse Effects

Few side effects

Drug Table

Drug Name	Application	Comments	Image
Lubiprostone			"Lube" "Professional" "Stone"