Clindamycin

Clindamycin is used in the treatment of strep, staph (including MRSA), and anaerobic infections.  Clindamycin binds the 50s subunit of ribosomes and inhibits protein synthesis. Clindamycin is primarily bacteriostatic.  Clindamycin can induce resistance with mechanisms of efflux pumps and enzymatic degradation.  While all antibiotics can promote development of C. difficile diarrhea, clindamycin is a well-known cause of C. difficile infections.

Class Drugs

• Clindamycin

Class Mechanism of Action

Binds 50s subunit inhibiting protein synthesis

Primarily bacteriostatic

Class Applications

Strep and Staph species including MRSA

Anaerobes

Class Adverse Effects

Inducible resistance

• Enzymatic inactivation

• Efflux pump

C. difficile diarrhea

Drug Table

Drug Name	Application	Comments	Image
Clindamycin			"Linda" "Mice"