Quinupristin/Dalfopristin

Quinupristin and dalfopristin are combination antibiotics that bind to separate areas on the 50s ribosome subunit, which inhibit protein synthesis. These medications are used to treat VRE that is resistant to other medications. Quinupristin and dalfopristin are bactericidal.  Resistance to these medications occurs from enzymatic inactivation and efflux pumps.  Adverse effects include venous irritation, arthralgias, and hyperbilirubinemia.  

Class Drugs

Quinupristin/Dalfopristin (30:70)

Class Mechanism of Action

Binds to separate 50s ribosome inhibiting protein synthesis

• Quinupristin limits elongation of peptide by inhibiting translocation step of protein synthesis

• Dalfopristin limits addition of amino acids during protein synthesis

Bactericidal

Class Applications

Vancomycin resistant Enterococcus faecium

Gram (+) infections

• MSSA

• MRSA

• Streptococcus pyogenes

Class Adverse Effects

Resistance

• Enzymatic inactivation

• Efflux pump

Venous irritation in peripheral veins

Arthralgias/myalgias

Hyperbilirubinemia

Drug Table

Drug Name	Application	Comments	Image
Quinupristin/Dalfopristin			"Dr. Quinn" "Dal" "Pristine