Linezolid

Linezolid is an antibiotic used to treat drug resistant infections including VRE, MRSA, and penicillin resistant strep infections. Linezolid works by inhibiting the 70s initiation complex by binding to the 23s ribosomal RNA on the 50s subunit.  Caution must be used with linezolid in combination with other serotonergic medications and MAOis.  Optic neuritis and thrombocytopenia are also possible side effects.

Class Drugs

• Linezolid

Class Mechanism of Action

Inhibits 70s initiation complex by binding to 23s ribosomal RNA of the 50s subunit

Bacteriostatic

Class Applications

Drug resistant gram (+) infections

• Vancomycin resistant Enterococcus (VRE)

• MRSA

• Penicillin resistant strep

Class Adverse Effects

Resistance

• Reduced affinity at binding site

MAOi

• Risk of serotonin syndrome

Optic neuritis in extended dosing

Thrombocytopenia

Drug Table

Drug Name	Application	Comments	Image
Linezolid			"Line" "Lid"