Clofazimine

Clofazimine is an antibiotic that is used in the treatment of leprosy. It's mechanism is likely from binding or oxidative damage to DNA from formation of oxygen free radicals.  Adverse effects include skin discoloration, severe GI disturbances, and prolonged QT interval. 

Class Drugs

• Clofazimine

Class Mechanism of Action

Unclear but may bind to DNA or cause oxidative damage from oxygen free radicals

Bactericidal

Class Application

Leprosy

Possible activity against TB and other nontuberculous mycobacteria

Class Adverse Effects

Skin discoloration 

• Colors range from pink to brown/black

Severe GI symptoms

Prolonged QT interval

Drug Table

Drug Name	Application	Comments	Image
Clofazimine			"Clover" "Phasor"