Daptomycin

Daptomycin is an antibiotic used to treat resistant gram-positive infections.  Daptomycin is bactericidal and works by disrupting the cell wall and efflux of potassium. Daptomycin also inhibits the production of RNA, DNA, and proteins.  Daptomycin has poor pulmonary penetration, so it should not be used to treat pneumonia.  Rhabdomyolysis can occur with use.

Class Drugs

• Daptomycin

Class Mechanism of Action

Proposed mechanisms of action:

• Lipophilic portion of daptomycin inserts into cell wall causing disruption and efflux of potassium

• Inhibits RNA/DNA/protein synthesis

• Bactericidal

Class Applications

Complicated skin infections

S. aureus bacteremia

Gram (+) Cocci

• S. aureus including MRSA

• S. pneumoniae

• Streptococcus pyogenes

• Enterococcus faecalis including VRE

• Enterococcus faecium

Gram (+) Bacilli

Class Adverse Effects

• Myopathy/rhabdomyolysis

Drug Table

Drug Name	Application	Comments	Image
Daptomycin		Poor pulmonary penetration; Do not use for treatment of pneumonia	"Dapper" "Toe" "Mice"