Telavancin

Telavancin is another antibiotic that works against complicated skin infections including MRSA and is also used to treat complicated pneumonias.  Telavancin works by inhibiting cell wall synthesis, disrupting the cell wall membrane. Telavancin is bactericidal.  QTc prolongation, altered taste, and risk of fetal harm in pregnancy are known adverse effects.

Class Drugs

• Telavancin

Class Mechanism of Action

Inhibits cell wall synthesis

Disrupts cell wall membrane

Bactericidal

Class Applications

Complicated skin infections

Pneumonia (hospital acquired and ventilator-associated)

Gram (+) Cocci

• S. aureus including MRSA

• S. pneumoniae

• Streptococcus pyogenes

• Enterococcus faecalis including VRE

• Enterococcus faecium

Gram (+) Bacilli

Class Adverse Effects

QTc prolongation

Fetal harm risk in pregnancy

Taste disturbance

Renal impairment

Drug Table

Drug Name	Application	Comments	Image
Telavancin		Poor side effect profile limits use to "last resort" antibiotic for pneumonia and staph skin infections	"Television" "Van"