Fosfomycin

Fosfomycin is a unique antibiotic that is used to treat urinary tract infections. Fosfomycin works by inhibiting cell wall synthesis by blocking the UDP-N-acetylglucosamine enolpyruvyl transferase enzyme.  Fosfomycin is bactericidal. Uniquely, fosfomycin concentrates in the urine for several days after a single dose of the medication, which allows a single dose administration to be used for completion of treatment.

Class Drugs

• Fosfomycin

Class Mechanism of Action

Inhibits cell wall synthesis

• Blocks UDP-N-acetylglucosamine enolpyruvyl transferase

Bactericidal

Class Applications

Single dose for UTI as concentrates in urine for several days after a single dose

• Enterococcus faecalis

• E. Coli

Class Adverse Effects

Diarrhea

Drug Table

Drug Name	Application	Comments	Image
Fosfomycin			"Phosphorus" "Foam" "Mice"