Polymyxins

Polymyxins are a group of antibiotics that are used to treat gram negative infections. Polymyxin B is typically used topically for susceptible infections and colistin can be administered parenterally. These medications disrupt bacterial cell wall integrity.  Nephrotoxicity and neurotoxicity are possible. 

Class Drugs

• Polymyxin B

• Colistin

Class Mechanism of Action

Disrupts integrity of cell wall

Bactericidal

Class Applications

Gram negative infections

Class Adverse Effects

Nephrotoxicity

Neurotoxicity

Drug Table

Drug Name	Application	Comments	Image
Polymyxin B			"Polly" "Mixer"
Colistin			"Collie" "Tin"