HIV Entry Inhibitors

Enfuvirtide and maraviroc are HIV entry inhibitors that function by binding to surface proteins on HIV, which prevents the alteration of shape needed for HIV to enter the cell.  Enfuvirtide binds to gp41 and maraviroc binds to CCR5.

Class Drugs

• Enfuvirtide

• Maraviroc

Class Mechanism of Action

Binding of surface proteins, which prevents the change of shape needed for HIV to enter the cell

Class Applications

HIV

Class Adverse Effects

• See individual drugs

Drug Table

Drug Name	Application	Comments	Image
Enfuvirtide		Mechanism; Binds gp41 (transmembrane glycoprotein) on HIV, which prevents change of shape/conformation to allow HIV to enter the cell; Adverse Reactions; Local injection site reactions	"Ent" "Virtue" "Tide"
Maraviroc		Mechanism; -Binds CCR5 (a co-receptor to gp41) on HIV, which prevents change of shape/conformation to allow HIV to enter the cell; -Some strains of HIV also express CXCR4 an alternative co-receptor to gp41, which makes maraviroc ineffective	"Mars" "Virtue" "Rock"