Integrase Inhibitors

Integrase inhibitors are used to treat HIV and work by binding to metal ions on the integrase enzyme of HIV, which inhibits HIV from inserting proviral DNA into the host DNA.  Resistance can develop from mutation of the integrase gene. Care must be taken to not administer with other ionized foods or medications, which would lower bioavailability.  

Class Drugs

• Dolutegravir

• Elvitegravir

• Raltegravir

Class Mechanism of Action

Binds to metal ions on integrase enzyme of HIV, rendering HIV ineffective at insertion of proviral DNA into the host DNA

Class Applications

HIV

Class Adverse Effects

Must be given separate from other cations/antacids or bioavailability will decrease

Resistance

• Mutation of integrase gene

Drug Table

Drug Name	Application	Comments	Image
Dolutegravir			"Dilute Gravy"
Elvitegravir			"Elvis" "Gravy"
Raltegravir		Adverse Reactions; Rhabdomyolysis; Suicidal ideation	"Rawlings Baseball" "Gravy"