IgE Monoclonal Antibodies - Asthma

Omalizumab is a monoclonal antibody with specificity of Immunoglobulin E or IgE.  IgE is an immunoglobulin that plays a critical role in allergic responses and in conditions such as asthma, atopic dermatitis, and allergic rhinitis.  Omalizumab is indicated for patients who have a documented perennial aeroallergen with moderate to severe asthma and works by binding IgE.  Omalizumab is also indicated in the treatment of severe food allergies. Adverse effects can include arthralgias, parasitic infections, allergic reactions, and malignancy with long term use.  

Class Drugs

• Omalizumab

Class Mechanism of Action

Selectively binds to IgE

• Limits allergic response (activation of mast cells and basophils)

Class Applications

Moderate to severe persistent asthma, poorly controlled

Severe food allergies

Chronic idiopathic hives

Class Adverse Effects

Anaphylaxis

Arthralgias

Fever

Rash

Drug Table

Drug Name	Application	Comments	Image
Omalizumab			"Omar" "Zoom" "Abs"