Phenothiazines

Prochlorperazine is a phenothiazine that is indicated for use as an antiemetic. Prochlorperazine works by antagonizing dopamine receptors in the brain. Prochlorperazine also blocks histamine, cholinergic, and noradrenergic receptors to varying degrees.  Adverse effects include akathisia, tardive dyskinesia, and dystonia.  Additionally, side effects related to anticholinergic and antihistamine effects can occur.

Class Drugs

• Prochlorperazine

Class Mechanism of Action

Dopamine receptor antagonist

• Histamine, cholinergic, and noradrenergic receptors also antagonized

Class Applications

Antiemetic

Class Adverse Effects

Akathisia

Tardive dyskinesia

Dystonia

Drug Table

Drug Name	Application	Comments	Image
Prochlorperazine			"Professional" "Clorox" "Pear"