Serotonin (5-HT3) Receptor Blockers

5-HT3 receptor blockers are used for the treatment of generalized nausea as well as for postoperative nausea, and chemotherapy induced nausea.  These medications interact with both central and peripheral serotonin receptors to mediate their effects.  QT prolongation can occur, especially with ondansetron.  Somnolence is a known side effect but is generally mild.

Class Drugs

• Granisetron

• Ondansetron

• Palonosetron

Class Mechanism of Action

Blocks 5-HT3 (serotonin) receptors both peripherally and centrally to reduce nausea

Class Applications

Chemotherapy induced nausea

Postoperative nausea

Used commonly for generalized nausea

Class Adverse Effects

Somnolence

Drug Table

Drug Name	Application	Comments	Image
Granisetron			"Granny" "Sat" "Ron"
Ondansetron		Adverse Effects; Prolonged QT Interval	"On Dan Sat Ron"
Palonosetron			"Pal" "Sat" "Ron"