Platinum-based Therapies

Carboplatin, cisplatin, and oxaliplatin are platinum-based compounds that bind to chloride when in plasma but release the platinum intracellularly, which allows the drug to bind to DNA. Binding to DNA limits DNA replication and synthesis of RNA. Platinum-based drugs can cause neurotoxicity, nephrotoxicity, and myelosuppression.

Class Drugs

• Carboplatin

• Cisplatin

• Oxaliplatin

Class Mechanism of Action

Bound to chloride in the plasma, but loses chloride intracellularly, which allows the drug to bind to DNA

• DNA replication and RNA synthesis is inhibited

Class Applications

See individual drugs

Class Adverse Effects

Ototoxicity

Nephrotoxicity

Myelosuppression

Hypersensitivity reaction

Drug Table

Drug Name	Application	Comments	Image
Carboplatin	Solid tumors; Ovarian cancer; Bladder cancer		"Carbon" "Plate"
Cisplatin	Solid tumors; Ovarian cancer; Bladder cancer		"Sister" "Plate"
Oxaliplatin	Colorectal Cancer		"Ox" "Plate"