Topoisomerase Inhibitors

Irinotecan and topotecan are topoisomerase I inhibitors, which is an essential enzyme in DNA replication. Etoposide inhibits topoisomerase II and the DNA complex, which leaves DNA susceptible to breakage.  Adverse effects include myelosuppression.

Class Drugs

Irinotecan

Topotecan

Etoposide

Class Mechanism of Action

See individual drugs

Class Applications

See individual drugs

Class Adverse Effects

Myelosuppression

Drug Table

Drug Name	Application	Comments	Image
Irinotecan	Colorectal Cancer	Mechanism; Inhibits topoisomerase I, which is a necessary enzyme in DNA replication	"Iron" "Toucan"
Topotecan	Ovarian cancer; Small Cell Lung Cancer	Mechanism; Inhibits topoisomerase I, which is a necessary enzyme in DNA replication	"Top Hat" "Toucan"
Etoposide	Lung Cancer; Testicular Cancer	Mechanism; Binds to topoisomerase II and DNA complex, which limits function of topoisomerase II and leaves DNA susceptible to breakage	"Top-Side"