Tyrosine Kinase Inhibitors

Tyrosine kinase inhibitors are chemotherapeutics that inhibits the tyrosine kinase enzymes.  Inhibition of tyrosine kinase limits downstream signaling pathways for growth, migration, differentiation, and apoptosis.  Imatinib, dasatinib, and nilotinib are known to cause QTc prolongation.

Class Drugs

• Imatinib

• Dasatinib

• Nilotinib

• Erlotinib

• Sorafenib

• Sunitinib

Class Mechanism of Action

Inhibition of tyrosine kinase enzymes in various tumor types, which results in reduced cell proliferation

Class Applications

See individual drugs

Class Adverse Effects

See individual drugs

Drug Table

Drug Name	Application	Comments	Image
Imatinib	CML	Adverse Effects; Prolonged QT interval	"Mat" "Tin Can" "Nibs"
Dasatinib	CML	Adverse Effects; Prolonged QT interval	"Dasani" "Tin Can" "Nibs"
Nilotinib	CML	Adverse Effects; Prolonged QT interval	"Nile River" "Tin Can" "Nibs"
Erlotinib	Non-small cell lung cancer; Pancreatic cancer		"Earlobe" "Nibs"
Sorafenib	Renal cell carcinoma; Hepatocellular carcinoma		"Sofa" "Nibs"
Sunitinib	Renal cell carcinoma; Pancreatic neuroendocrine tumors		"Sun" "Tin Can" "Nibs"