Procoagulants and Reversal Agents

This grouping of drugs includes medications that help restore hemostasis in the setting of bleeding.  

Class Drugs

• Aminocaproic Acid

• Tranexamic Acid

• Protamine sulfate

• Vitamin K

• Idarucizumab

Class Mechanism of Action

See individual drugs

Class Applications

See individual drugs

Class Adverse Effects

See individual drugs

Drug Table

Drug Name	Application	Comments	Image
Aminocaproic Acid	Treatment of bleeding	Mechanism of Action; Inhibition of plasminogen activation; Adverse Effects; Theoretical risk of thrombosis	"Minnow" "Cap" "Row"
Tranexamic Acid	Treatment of bleeding	Mechanism of Action; Inhibition of plasminogen activation; Adverse Effects; Theoretical risk of thrombosis	"Train" "Exam"
Protamine Sulfate	Treatment of bleeding related to heparin use	Mechanism of Action; Forms stable complex with heparin; Eliminates anticoagulant effect; Adverse Effects; Hypersensitivity; Bradycardia; Hypotension; Flushing; Bleeding (when administered in excess)	"Proton" "Mine"
Vitamin K	Treatment of bleeding related to coumadin use; Slow onset, so if severe or life-threatening bleeding consider concentrated factors or fresh frozen plasma (FFP)	Mechanism of Action; Repletes supply of active vitamin K; Adverse Effects; Hypersensitivity; Anaphylactoid reaction	"Special K Cereal Box"
Idarucizumab	Treatment of bleeding related to dabigatran usage	Mechanism of Action; Binds to dabigatran	"Idaho" "Zubaz pants"