Statins

Statins are widely used drugs in the treatment of hyperlipidemia. Statins inhibit HMG CoA reductase, which results in reduced synthesis of intracellular cholesterol.  Reduced intracellular cholesterol promotes cell uptake of plasma cholesterol.  Statins can elevate liver enzymes and cause myalgias and rhabdomyolysis.  

Class Drugs

• Atorvastatin

• Fluvastatin

• Lovastatin

• Pitavastatin

• Pravastatin

• Simvastatin

Class Mechanism of Action

HMG CoA Reductase Inhibitor

• Reduces synthesis of intracellular cholesterol, which results in cell uptake of plasma cholesterol

Class Applications

Hyperlipidemia

• Reduces levels of LDL

• Also reduces triglycerides and may increase HDL levels

Class Adverse Effects

• Elevated liver enzymes

• Rhabdomyolysis

• Myalgias

• Contraindicated in pregnancy and breastfeeding mothers

Drug Table

Drug Name	Application	Comments	Image
Atorvastatin			"A Tore Stats Book"
Fluvastatin			"Flue" "Stats Book"
Lovastatin			"Love Stats Book"
Pitavastatin			"Pita" "Vast Stats Book"
Pravastatin			"Prada" "Stats Book"
Simvastatin			"Sims" "Stats Book"