Urate-lowering Drugs

Elevated levels of uric acid can precipitate gout. Gout is a condition in which uric acid crystals are deposited into joints. Uric acid crystals result in painful, swollen, and erythematous joints. Prevention of gout attacks is accomplished by lowering uric acid levels.  Xanthine oxidase inhibitors (allopurinol and febuxostat) reduce uric acid levels by inhibiting the production of uric acid.  Probenecid works by increasing renal clearance of uric acid and pegloticase is an enzyme that converts uric acid to allantoin.  

Class Drugs

• Allopurinol

• Febuxostat

• Probenecid

• Pegloticase

Class Mechanism of Action

See individual drugs

Class Applications

See individual drugs

Class Adverse Effects

See individual drugs

Drug Table

Drug Name	Application	Comments	Image
Allopurinol	Gout; Hyperuricemia	Mechanism of Action; Xanthine oxidase inhibitor; Adverse Effects; Rash	"Alo Yoga" "Pure"
Febuxostat	Gout; Hyperuricemia	Mechanism of Action; Xanthine oxidase inhibitor	"February" "STAT"
Probenecid	Chronic Gout	Mechanism of Action; -Promotes renal clearance of uric acid; -Urate-anion exchanger inhibitor in proximal tubule of kidney	"Probe" "Acid"
Pegloticase	Chronic Gout	Mechanism of Action; -Recombinant urate oxidase; -Converts uric acid to allantoin	"Peg" "Lot" "Case"