Vinca Alkaloids

Vinca alkaloids are chemotherapeutic agents that work by blocking assembly of microtubules in the M-phase of mitosis.  This action inhibits cell division.  Vincristine and vinblastine are known to cause neurotoxicity.

Class Drugs

• Vincristine

• Vinblastine

Class Mechanism of Action

• Blocks assembly of microtubules used for cell division (M-phase of mitosis)

Class Applications

• See individual drugs

Class Adverse Effects

• Neurotoxicity

Drug Table

Drug Name	Application	Comments	Image
Vincristine	Lymphomas; ALL; Wilms tumor; Ewing  sarcoma		"VIN number" "Christie"
Vinblastine	Lymphoma; Testicular cancer		"VIN number" "Blast"