Taxanes

Paclitaxel and docetaxel are taxanes that are chemotherapeutic agents. Taxanes work by polymerizing and stabilizing microtubules, which limits the microtubules' typical function.  Neutropenia and leukopenia can occur with administration of these medications.

Class Drugs

Paclitaxel

Docetaxel

Class Mechanism of Action

• Polymerizes and stabilizes microtubules, rendering the microtubules non-functional

Class Applications

• See individual drugs

Class Adverse Effects

• Neutropenia, leukopenia

• Hypersensitivity reactions (premedication with steroids recommended)

Drug Table

Drug Name	Application	Comments	Image
Paclitaxel	Ovarian cancer; Breast cancer; Non-small cell lung cancer		"Pac-Man" "Taxi"
Docetaxel	Breast cancer; Prostate cancer		"Dose" "Taxi"