Griseofulvin

Griseofulvin is used to treat onychomycosis (fungal infection of the toenail) and works by inhibition of mitosis through disruption of the mitotic spindle.  Griseofulvin induces the CYP450 system, so drug-drug interactions occur. Griseofulvin is also contraindicated in pregnancy.  

Class Drugs

• Griseofulvin

Class Mechanism of Action

Inhibits mitosis by disrupting mitotic spindle

Class Application

Onychomycosis

Class Adverse Effects

Drug-drug interactions

• Induces CYP450

Contraindicated in pregnancy

Contraindicated in porphyria

Drug Table

Drug Name	Application	Comments	Image
Griseofulvin			"Grits" "Fulcrum"