Squalene Epoxidase Inhibitors

As the class name suggests, squalene epoxidase inhibitors are antifungals that inhibit the production of ergosterol, an important component of the fungal cell wall, by inhibition of the squalene epoxidase enzyme. These medications are used in the treatment of tinea infections.  

Class Drugs

Terbinafine

Naftifine

Butenafine

Class Mechanism of Action

Inhibits squalene epoxidase, which is used in production of ergosterol. Ergosterol is an important component of the fungal cell wall

Class Applications

Tinea cruris

Tinea corporis

Tinea pedis

Class Adverse Effects

Rash

Drug Table

Drug Name	Application	Comments	Image
Terbinafine	Onychomycosis	Adverse Effects; GI disturbance; Visual disturbance	"Turbine" "Fine"
Naftifine			"NAFTA" "Fine"
Butenafine			"Butane Torch" "Fine"